Validation of Metagenomic Next-Generation Sequencing Tests for Universal Pathogen Detection.

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Archives of pathology & laboratory medicine, ISSN: 1543-2165, Vol: 141, Issue: 6, Page: 776-786

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Schlaberg, Robert; Chiu, Charles Y; Miller, Steve; Procop, Gary W; Weinstock, George; Professional Practice Committee and Committee on Laboratory Practices of the American Society for Microbiology; Microbiology Resource Committee of the College of American Pathologists
Archives of Pathology and Laboratory Medicine; College of American Pathologists
Medicine; Health Professions; Life Sciences; Medicine and Health Sciences
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- Metagenomic sequencing can be used for detection of any pathogens using unbiased, shotgun next-generation sequencing (NGS), without the need for sequence-specific amplification. Proof-of-concept has been demonstrated in infectious disease outbreaks of unknown causes and in patients with suspected infections but negative results for conventional tests. Metagenomic NGS tests hold great promise to improve infectious disease diagnostics, especially in immunocompromised and critically ill patients.