MICA and Recovery from Hepatitis C Virus and Hepatitis B Virus Infections

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Genes and Immunity, Vol: 5, Issue: 4, Page: 261-266

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Karacki, Peter; Gao, Xiaojiang; Thio, Chloe L.; Thomas, D. L.; Goedert, James J.; Vlahov, David; Kaslow, Richard A.; Strathdee, Steffanie A.; Hilgartner, Margaret; O'Brien, Stephen J.; Carrington, Mary Show More Hide
HCV; HBV; MICA; Genetics; Viral persistence; Pathogenesis; Genetics and Genomics; Immunology and Infectious Disease; Medicine and Health Sciences
article description
The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval=0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.