Mechanistic Studies and Optimization of Microwave-Assisted Palladium-Catalyzed Carbon-Carbon Bond Forming Reactions and an Academic Prospective on “Quality by Design”

Publication Year:
2012
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Downloads 702
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Repository URL:
https://opencommons.uconn.edu/srhonors_theses/267
Author(s):
Grewal, Neha K.
Tags:
Quality by Design; chemistry; Palladium; Diarylmethanes; Raman Spectroscopy; microwave; Suzuki Coupling; Click; Chemistry
article description
This compilation of work includes four aspects: (1) an academic review on the significance and implementation of Quality by Design (QbD), (2) mechanistic studies on the palladium-catalyzed synthesis of diarylmethanes, (3) the optimization of microwave-assisted click reactions and Suzuki couplings for use in an undergraduate organic chemistry laboratory manual, and (4) monitoring the progress of organic transformations using Raman spectroscopy.