Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine.
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Journal of ethnopharmacology, ISSN: 1872-7573, Vol: 148, Issue: 3, Page: 770-9
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- Pharmacology, Toxicology and Pharmaceutics; Bioinformatics; Herbal medicine; Ingenuity Pathway Analysis; Property; Tradition Chinese medicine
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Chinese herbal medicines (HMs) is one of the great herbal systems of the world, which play an important role in current health care system in many countries. In the view of tradition Chinese medicine (TCM) theory, Yin-yang and five-elements theory is the central theory, which is used to explain how the world and body work. Under the guidance of such philosophy, TCM considers that HMs have different properties, which are the important factors for prescribing herbal formulae; such prescriptions are based on TCM pattern classification in clinical practice. The cold and hot property are commonly defined for HM property identification; however, the biological activities that are related to the HM property remain a mystery because of a lack of appropriate methods. A bioinformatics approach was applied to identify the distinguishing biological activities of HMs that have these cold and hot properties.