Lecture 28: Protein folding and unfolding

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Winter, Nathan S.
biochemistry; protein folding; denaturation; chaotropic; anfinsen; ribonuclease a; Biochemistry; Biochemistry, Biophysics, and Structural Biology; Chemistry
lecture / presentation description
This lecture in Biochemistry addressees denaturation and the folding problem. Some of the means to denature a protein are mentioned, including temperature, pH, hydrophobic solvents, detergents and chaotropic reagents (urea and the guanidinium ion). How proteins (which are synthesized like beads on a string) fold to functional tertiary structures are examined with particular attention spent on ribonuclease A.. The steps and energetics of the folding process are discussed.