Electrical stimulation promotes nerve cell differentiation on polypyrrole/poly (2-methoxy-5 aniline sulfonic acid) composites.

Citation data:

Journal of neural engineering, ISSN: 1741-2552, Vol: 6, Issue: 6, Page: 065002

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Repository URL:
https://ro.uow.edu.au/aiimpapers/389; https://works.bepress.com/gwallace/40; http://hdl.handle.net/1959.3/396586
Liu, Xiao; Gilmore, Kerry J.; Moulton, Simon E.; Wallace, Gordon G.
IOP Publishing; Institute of Physics Publishing
Engineering; Neuroscience; Physical Sciences and Mathematics
article description
The purpose of this work was to investigate for the first time the potential biomedical applications of novel polypyrrole (PPy) composites incorporating a large polyelectrolyte dopant, poly (2-methoxy-5 aniline sulfonic acid) (PMAS). The physical and electrochemical properties were characterized. The PPy/PMAS composites were found to be smooth and hydrophilic and have low electrical impedance. We demonstrate that PPy/PMAS supports nerve cell (PC12) differentiation, and that clinically relevant 250 Hz biphasic current pulses delivered via PPy/PMAS films significantly promote nerve cell differentiation in the presence of nerve growth factor (NGF). The capacity of PPy/PMAS composites to support and enhance nerve cell differentiation via electrical stimulation renders them valuable for medical implants for neurological applications.