Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.

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PLoS medicine, ISSN: 1549-1676, Vol: 5, Issue: 2, Page: e45

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10.1371/journal.pmed.0050045; 10.1371/journal.pmed.0050045.g003; 10.1371/journal.pmed.0050045.g004; 10.1371/journal.pmed.0050045.g001; 10.1371/journal.pmed.0050045.g002
PMC2253608; 2253608
Irving Kirsch; Brett J Deacon; Tania B Huedo-Medina; Alan Scoboria; Thomas J Moore; Blair T Johnson; Phillipa Hay
Public Library of Science (PLoS); Figshare
Medicine; severity; antidepressant; benefits; meta; initial; analysis; administration; data; submitted; food; drug; Infectious Diseases; Mental Health; evidence-based healthcare; Mental health; standardized; treatment; trials; samples; had; Cancer; meta-analysis; scores; 111714 Mental Health; 110309 Infectious Diseases; Education; Social and Behavioral Sciences
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Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depression scores. The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials.