Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.

Citation data:

PLoS medicine, ISSN: 1549-1676, Vol: 5, Issue: 2, Page: e45

Publication Year:
Usage 461251
Full Text Views 457811
Abstract Views 2409
Views 598
Clicks 254
Downloads 120
Link-outs 59
Captures 1513
Readers 1305
Exports-Saves 208
Mentions 52
News Mentions 18
Blog Mentions 17
References 15
Economics Blog Mentions 1
Q&A Site Mentions 1
Social Media 823
Shares, Likes & Comments 669
Tweets 154
Citations 1412
Citation Indexes 1401
Clinical Citations 11
Reddit 10
Repository URL:
10.1371/journal.pmed.0050045; 10.1371/journal.pmed.0050045.g003; 10.1371/journal.pmed.0050045.g004; 10.1371/journal.pmed.0050045.g001; 10.1371/journal.pmed.0050045.g002
PMC2253608; 2253608
Irving Kirsch; Brett J Deacon; Tania B Huedo-Medina; Alan Scoboria; Thomas J Moore; Blair T Johnson; Phillipa Hay
Public Library of Science (PLoS); Figshare
Medicine; severity; antidepressant; benefits; meta; initial; analysis; administration; data; submitted; food; drug; Infectious Diseases; Mental Health; evidence-based healthcare; Mental health; standardized; treatment; trials; samples; had; Cancer; meta-analysis; scores; Education; Social and Behavioral Sciences
Most Recent Tweet View All Tweets
Most Recent Blog Mention
Most Recent Economics Blog Mention
Most Recent News Mention
article media
article description
Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depression scores. The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials.