Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.

Citation data:

PLoS medicine, ISSN: 1549-1676, Vol: 5, Issue: 2, Page: e45

Publication Year:
2008
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Repository URL:
http://ro.uow.edu.au/sspapers/2072
PMID:
18303940
DOI:
10.1371/journal.pmed.0050045; 10.1371/journal.pmed.0050045.g003; 10.1371/journal.pmed.0050045.g004; 10.1371/journal.pmed.0050045.g001; 10.1371/journal.pmed.0050045.g002
PMCID:
PMC2253608; 2253608
Author(s):
Irving Kirsch; Brett J Deacon; Tania B Huedo-Medina; Alan Scoboria; Thomas J Moore; Blair T Johnson; Phillipa Hay
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Medicine; severity; antidepressant; benefits; meta; initial; analysis; administration; data; submitted; food; drug; Infectious Diseases; Mental Health; evidence-based healthcare; Mental health; standardized; treatment; trials; samples; had; Cancer; meta-analysis; scores; 111714 Mental Health; 110309 Infectious Diseases; Education; Social and Behavioral Sciences
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article description
Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also depend on the severity of initial depression scores. The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials.