Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.

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Neural development, ISSN: 1749-8104, Vol: 11, Issue: 1, Page: 19

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Junge, Harald J; Yung, Andrea R; Goodrich, Lisa V; Chen, Zhe
Springer Nature
Neuroscience; Animals; Cell Movement; DCC Receptor; Interneurons; Membrane Proteins; Mice; Knockout; Nerve Growth Factors; Nerve Tissue Proteins; Netrin-1; Neural Stem Cells; Receptors; Cell Surface; Signal Transduction; Spinal Cord; Tumor Suppressor Proteins
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Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during development. In the developing spinal cord, neuroprogenitors first undergo radial migration within the ventricular zone. Differentiated neurons continue to migrate tangentially before reaching the final positions. The molecular pathways that regulate these migration processes remain largely unknown. Our previous study suggests that the DCC receptor is important for the migration of the dorsal spinal cord progenitors and interneurons. In this study, we determined the involvement of the Netrin1 ligand and the ROBO3 coreceptor in the migration.