Analysis of glutamatergic and gabaergic receptor dynamics in coupled oscillator neural model

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International Journal of Modelling and Simulation, ISSN: 0228-6203, Vol: 33, Issue: 3, Page: 144-151

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Dr. M. Hamza; Saleh Ramezani; Wu Chen; Alan W.L. Chiu
ACTA Press
Computer Science; Mathematics; Engineering; Analysis; Glutamatergic; GABAergic Receptor Dynamics; Coupled Oscillator; Neural Model; Biological Engineering; Biomedical Engineering and Bioengineering
article description
The hippocampus plays a crucial role in information storage and is associated with long-term episodic and semantic memories. It is frequently used as a test bed for the development and evaluation of neural prosthetic devices for cognitive function restoration. Here, a modification of the mapped clock oscillator (MCO) model representation of the hippocampal CA3 region was developed. We addressed several limitations with the experimental design of the existing MCO model. It was modified to include kinetics of N-methyl-d-aspartate (NMDA), a-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) and ?-aminobutyric acid (GABAA) receptors, capable of generating activity in close agreement with experimental results. The model response showed that lower than normal magnesium concentrations will increase the network excitability in the absence of AMPA and GABAA receptors. In a network of reciprocally connected MCOs, effective synaptic excitation will increase the excitability of the network, while effective synaptic inhibition would push the network towards less excitable states. The new glutamatergic and GABAergic receptor pathways were also designed to be adaptive, making them more suitable for the future integration with a hippocampal system for cognitive neural prosthesis.