A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein.

Citation data:

The Journal of nutrition, ISSN: 1541-6100, Vol: 139, Issue: 12, Page: 2365-72

Publication Year:
2009
Usage 836
Abstract Views 824
Link-outs 12
Captures 244
Readers 206
Exports-Saves 38
Mentions 4
News Mentions 2
References 1
Blog Mentions 1
Social Media 187
Tweets 149
Shares, Likes & Comments 38
Citations 132
Citation Indexes 132
Repository URL:
https://works.bepress.com/may/48; https://escholarship.umassmed.edu/prevbeh_pp/56; https://scholarcommons.sc.edu/sph_epidemiology_biostatistics_facpub/295
PMID:
19864399
DOI:
10.3945/jn.109.114025
PMCID:
PMC2777480
Author(s):
Cavicchia, Philip P.; Steck, Susan E.; Hurley, Thomas G.; Hussey, James R.; Ma, Yunsheng; Ockene, Ira S.; Hébert, James R.
Publisher(s):
Oxford University Press (OUP)
Tags:
Medicine; Nursing; dietary inflammatory index; serum high-sensitivity C-reactive protein; Public Health; Adult; Biological Markers; C-Reactive Protein; Diet; Energy Intake; Exercise; Female; Homeostasis; Humans; Inflammation; Interleukin-1; Interleukin-10; Interleukin-4; Interleukin-6; Interviews as Topic; Male; Middle Aged; Reference Values; Search Engine; Sensitivity and Specificity; Tumor Necrosis Factor-alpha; Behavioral Disciplines and Activities; Behavior and Behavior Mechanisms; Community Health and Preventive Medicine; Preventive Medicine
Most Recent Tweet View All Tweets
Most Recent Blog Mention
Most Recent News Mention
article description
Inflammation is associated with a number of chronic conditions, such as cancer and cardiovascular disease. Reducing inflammation may help prevent or treat these conditions. Diet has consistently been shown to modulate inflammation. To facilitate research into the inflammatory effect of diet on health in humans, we sought to develop and validate an Inflammatory Index designed to assess the inflammatory potential of individuals' diets. An Inflammatory Index was developed based on the results of an extensive literature search. Using data from a longitudinal observational study that carefully measured diet and the inflammatory marker, serum high-sensitivity (hs) C-reactive protein (CRP), in approximately 600 adults for 1 y, we conducted analyses to test the effect of Inflammatory Index score on hs-CRP as a continuous and dichotomous (3 mg/L) indicator of inflammatory response, while controlling for important potential confounders. Results based on continuous measures of hs-CRP suggested that an increasing Inflammatory Index score (representing movement toward an antiinflammatory diet) was associated with a decrease in hs-CRP. Analyses using hs-CRP as a dichotomous variable showed that an antiinflammatory diet was associated with a decrease in the odds of an elevated hs-CRP (P = 0.049). The results are consistent with the ability of the Inflammatory Index to predict hs-CRP and provide additional evidence that diet plays a role in the regulation of inflammation, even after careful control of a wide variety of potential confounders.