High efficient electrical stimulation of hippocampal slices with vertically aligned carbon nanofiber microbrush array.

Citation data:

Biomedical microdevices, ISSN: 1572-8781, Vol: 11, Issue: 4, Page: 801-8

Publication Year:
2009
Usage 27
Abstract Views 27
Captures 52
Readers 52
Citations 36
Citation Indexes 36
Repository URL:
https://scholarcommons.scu.edu/elec/32
PMID:
19291408
DOI:
10.1007/s10544-009-9295-7; 10.1007/s10544-009-9295-7 (8 pp) (2009), online at www.springerlink.com
PMCID:
PMC2708324
Author(s):
de Asis, Edward D., Jr.; Nguyen-Vu, T. D. Barbara; Arumugam, Prabhu U.; Chen, Hua; Cassell, Alan M.; Andrews, Russell J.; Yang, Cary Y.; Li, Jun
Publisher(s):
Springer Nature; Springer
Tags:
Engineering; Biochemistry, Genetics and Molecular Biology; Vertically aligned carbon nanofiber; Electrical stimulation; Neural electrical interface; Hippocampal brain slice; Neural recording
article description
Long-term neuroprostheses for functional electrical stimulation must efficiently stimulate tissue without electrolyzing water and raising the extracellular pH to toxic levels. Comparison of the stimulation efficiency of tungsten wire electrodes (W wires), platinum microelectrode arrays (PtMEA), as-grown vertically aligned carbon nanofiber microbrush arrays (VACNF MBAs), and polypyrrole coated (PPy-coated) VACNF MBAs in eliciting field potentials in the hippocampus slice indicates that, at low stimulating voltages that preclude the electrolysis of water, only the PPy-coated VACNF MBA is able to stimulate the CA3 to CA1 pathway. Unlike the W wires, PtMEA, as-grown VACNF MBA, and the PPy-coated VACNF MBA elicit only excitatory postsynaptic potentials (EPSPs). Furthermore, the PPy-coated VACNF MBA evokes somatic action potentials in addition to EPSPs. These results highlight the PPy-coated VACNF's advantages in lower electrode impedance, ability to stimulate tissue through a biocompatible chloride flux, and stable vertical alignment in liquid that enables access to spatially confined regions of neuronal cells.