Peptide antagonists of tumor necrosis factor alpha

Publication Year:
2002
Usage 12
Abstract Views 7
Downloads 5
Repository URL:
https://scholarcommons.usf.edu/usf_patents/796
Author(s):
Liu, Richard Y.; Zuckerman, Kenneth S.
patent description
There is provided a method of inhibiting TNF-α from binding to TNF receptors by administering an effective amount of an inhibitory peptide. Also provided is a method of inhibiting TNF-α functions by administering an effective amount of an inhibitory peptide. There also are provided peptides which have TNF-α inhibitory properties. Also provided is a method of inhibiting TNF-α binding to TNF receptors by administering an effective amount of peptides having the amino acid sequences shown in SEQ ID No. 1,2,3,4, wherein the peptides can be administered either singly or in combination.