UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production. Discovery of netrinsThe term netrin was fi...
Selecting synaptic partners: GRASPing the role of UNC-6/netrin.
- Citation data:
BMC biology, ISSN: 1741-7007, Vol: 9, Issue: 1, Page: 43
- Publication Year:
- Repository URL:
- https://scholarworks.sjsu.edu/biol_pub/36; https://works.bepress.com/miri_vanhoven/3
- 10.1186/1741-7007-9-43; 10.1186/1741-7007-9-43.
- Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Biology
Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.