Selecting synaptic partners: GRASPing the role of UNC-6/netrin.

Citation data:

BMC biology, ISSN: 1741-7007, Vol: 9, Issue: 1, Page: 43

Publication Year:
2011
Usage 71
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Repository URL:
https://scholarworks.sjsu.edu/biol_pub/36; https://works.bepress.com/miri_vanhoven/3
PMID:
21663686
DOI:
10.1186/1741-7007-9-43; 10.1186/1741-7007-9-43.
PMCID:
PMC3112191
Author(s):
Ch'ng, QueeLim
Publisher(s):
Springer Nature
Tags:
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Biology
article description
Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.