Protective effect of centipedegrass against Aβ oligomerization and Aβ-mediated cell death in PC12 cells.
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Pharmaceutical biology, ISSN: 1744-5116, Vol: 53, Issue: 9, Page: 1260-6
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- Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine; Alzheimer's disease; neurotoxicity; β-secretase; Amyloid Precursor Protein Secretases; Amyloid beta-Peptides; Animals; Aspartic Acid Endopeptidases; Cell Death; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Fluorescence Resonance Energy Transfer; Glucosides; Humans; Neurons; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Phytotherapy; Plant Extracts; Plants, Medicinal; Poaceae; Protein Aggregation, Pathological; Rats; Cell Biology; Enzymes and Coenzymes
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid (Aβ). Multiple Aβ-aggregated species have been identified, and neurotoxicity appears to be correlated with the amount of non-fibrillar oligomers. Potent inhibitors of Aβ oligomer formation or Aβ-induced cell toxicity have emerged as attractive means of therapeutic intervention. Eremochloa ophiuroide Hack. (Poaceae), also known as centipedegrass (CG), originates from China and South America and is reported to contain several C-glycosyl flavones and phenolic constituents.