Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid.

Citation data:

Current opinion in nephrology and hypertension, ISSN: 1473-6543, Vol: 26, Issue: 2, Page: 74-82

Publication Year:
2016
Captures 8
Readers 8
Citations 6
Citation Indexes 6
Repository URL:
https://touroscholar.touro.edu/nymc_fac_pubs/438
PMID:
27906746
DOI:
10.1097/mnh.0000000000000302
Author(s):
Garcia, Victor; Schwartzman, Michal L
Publisher(s):
Ovid Technologies (Wolters Kluwer Health); Touro Scholar
Tags:
Medicine; Endothelial Cells/physiology; Hydroxyeicosatetraenoic Acids; Hypertension; Muscle; Smooth; Vascular; Myocytes; Smooth Muscle; Medicine and Health Sciences; Pharmacology
review description
20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid and a key constituent of the microcirculation. Its effects on vascular function are multifaceted and include stimulation of smooth muscle, contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation. Such effects have significant implications with regard to the control of vascular homeostasis and pathophysiology. The clinical relevance of 20-HETE is highlighted by recent studies linking 20-HETE and its biosynthetic enzymes to the development of hypertension, stroke, and myocardial infarction.