ADRB2 Arg16Gly polymorphism, lung function, and mortality: results from the Atherosclerosis Risk in Communities study.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 2, Issue: 3, Page: e289

Publication Year:
2007
Usage 5428
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Repository URL:
https://uknowledge.uky.edu/internalmedicine_facpub/8; https://works.bepress.com/david_mannino/253
PMID:
17356698
DOI:
10.1371/journal.pone.0000289; 10.1371/journal.pone.0000289.t003; 10.1371/journal.pone.0000289.t005; 10.1371/journal.pone.0000289.g002; 10.1371/journal.pone.0000289.t004; 10.1371/journal.pone.0000289.t002; 10.1371/journal.pone.0000289.t001; 10.1371/journal.pone.0000289.g001
PMCID:
PMC1808432; 1808432
Author(s):
Jill M. Ferdinands; David M. Mannino; Marta L. Gwinn; Molly S. Bray; Florian Kronenberg
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Amino Acid Substitution; Atherosclerosis; Cohort Studies; Female; Follow-Up Studies; Humans; Lung; Male; Middle Aged; Mutation; Missense; Polymorphism; Genetic; Probability; Receptors; Adrenergic; beta-2; Respiratory Function Tests; Risk Factors; Smoking; United States; Infectious Diseases; Genetics; Biotechnology; adjusted; ratios; baseline; beta-agonist; genetics and genomics; public health and epidemiology; respiratory medicine; respiratory medicine/asthma; Cancer; arg16gly; results; atherosclerosis; communities; genotypic; genotype; subjects; deaths; follow-up; Medicine and Health Sciences
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article description
Growing evidence suggests that the Arg16Arg genotype of the beta-2 adrenergic receptor gene may be associated with adverse effects of beta-agonist therapy. We sought to examine the association of beta-agonist use and the Arg16Gly polymorphism with lung function and mortality among participants in the Atherosclerosis Risk in Communities study.