ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis.
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Molecular cancer, ISSN: 1476-4598, Vol: 15, Issue: 1, Page: 52
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- Biochemistry, Genetics and Molecular Biology; Medicine; Alcohol; Cancer stem cell; p38 gamma; MCF7-ErbB2; Metastasis; Tumor promotion; Medical Nutrition; Medical Pharmacology; Oncology; Pharmacology, Toxicology and Environmental Health
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Both epidemiological and experimental studies suggest that excessive alcohol exposure increases the risk for breast cancer and enhances metastasis/recurrence. We have previously demonstrated that alcohol enhanced the migration/invasion of breast cancer cells and cancer cells overexpressing ErbB2/HER2 were more sensitive to alcohol exposure. However, the underlying mechanisms remain unclear. This study was designed to investigate the mechanisms underlying alcohol-enhanced aggressiveness of breast cancer. Cancer stem cells (CSCs) play a critical role in cancer metastasis and recurrence.