Translational models for vascular cognitive impairment: a review including larger species.
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BMC medicine, ISSN: 1741-7015, Vol: 15, Issue: 1, Page: 16
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- Medicine; Vascular dementia; Vascular cognitive impairment; VCID; Experimental models; In vivo models; Translational models; Diseases; Medical Nutrition; Medical Pharmacology; Pharmacology, Toxicology and Environmental Health; Translational Medical Research
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Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited.