FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.

Citation data:

Antioxidants & redox signaling, ISSN: 1557-7716, Vol: 20, Issue: 10, Page: 1550-66

Publication Year:
2014
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Repository URL:
https://uknowledge.uky.edu/toxicology_facpub/20; https://uknowledge.uky.edu/toxicology_facpub/22; https://uknowledge.uky.edu/toxicology_facpub/21
PMID:
23834335; 23901781; 24094070
DOI:
10.1089/ars.2012.4984; 10.1089/ars.2013.5529; 10.1089/ars.2012.5000
PMCID:
PMC3942683; PMC3960848; PMC3942704
Author(s):
Dhar, Sanjit Kumar; Zhang, Jiayu; Gal, Jozsef; Xu, Yong; Miao, Lu; Lynn, Bert C.; Zhu, Haining; Kasarskis, Edward J.; St. Clair, Daret K.
Publisher(s):
Mary Ann Liebert Inc; Mary Ann Liebert, Inc.
Tags:
Biochemistry, Genetics and Molecular Biology; redox-modulated phenomena; radiation therapy; superoxide dismutases; oxidative DNA damage; cancer; DNA Base Excision Repair; FUsed in Sarcoma; Gene Transcription; Novel regulator; Medical Toxicology
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review description
FUsed in sarcoma (FUS) is a multifunctional DNA/RNA-binding protein that possesses diverse roles, such as RNA splicing, RNA transport, DNA repair, translation, and transcription. The network of enzymes and processes regulated by FUS is far from being fully described. In this study, we have focused on the mechanisms of FUS-regulated manganese superoxide dismutase (MnSOD) gene transcription.