FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.

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Antioxidants & redox signaling, ISSN: 1557-7716, Vol: 20, Issue: 10, Page: 1550-66

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https://uknowledge.uky.edu/toxicology_facpub/20; https://uknowledge.uky.edu/toxicology_facpub/22; https://uknowledge.uky.edu/toxicology_facpub/21
23834335; 23901781; 24094070
10.1089/ars.2012.4984; 10.1089/ars.2013.5529; 10.1089/ars.2012.5000
PMC3942683; PMC3960848; PMC3942704
Dhar, Sanjit Kumar; Zhang, Jiayu; Gal, Jozsef; Xu, Yong; Miao, Lu; Lynn, Bert C.; Zhu, Haining; Kasarskis, Edward J.; St. Clair, Daret K.
Mary Ann Liebert Inc; Mary Ann Liebert, Inc.
Biochemistry, Genetics and Molecular Biology; redox-modulated phenomena; radiation therapy; superoxide dismutases; oxidative DNA damage; cancer; DNA Base Excision Repair; FUsed in Sarcoma; Gene Transcription; Novel regulator; Medical Toxicology
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review description
FUsed in sarcoma (FUS) is a multifunctional DNA/RNA-binding protein that possesses diverse roles, such as RNA splicing, RNA transport, DNA repair, translation, and transcription. The network of enzymes and processes regulated by FUS is far from being fully described. In this study, we have focused on the mechanisms of FUS-regulated manganese superoxide dismutase (MnSOD) gene transcription.