PlumX Metrics
Embed PlumX Metrics

Experimental model for evaluating the effects of genetic and exogenous factors on transplacental mutagenesis

Mutagenesis, ISSN: 0267-8357, Vol: 2, Issue: 3, Page: 173-177
1987
  • 4
    Citations
  • 0
    Usage
  • 7
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Cyclophosphamide (CP)-induced micronuclei were evaluated in females of two strains of mice (C57BL and CD1), in F hybrid females and in fetuses (day 13 of gestation) obtained from different crosses. F adult hybrids from a cross between the strain with a high level of induced micronuclei (C57BL) and the strain with a low response (CD1) exhibited micronuclei values closer to the latter. CD1/CD1 fetuses showed a higher susceptibility than C57BL/C57BL ones. Heterozygous fetuses from reciprocal crosses, whatever the maternal genotype, showed the same sensitivity, which is very close to that of C57BL/C57BL fetuses. Phenobarbital (PB) pre-treatment modified the mutagenic response to CP depending on the genotype of the treated animal. These results demonstrate that the response to a pro-mutagen requiring metabolic activation depends to a large extent on the genetic background of the target animals, and that mother-fetus interactions in transplacental mutagenesis seem to depend more on the fetal than on the maternal genotype. © 1987 IRL Press Ltd.

Bibliographic Details

R. Barale; L. Migliore; D. Zucconi; R. Ciranni; D. Casini; A. Carducci; N. Loprieno

Oxford University Press (OUP)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine; Environmental Science

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know