Experimental model for evaluating the effects of genetic and exogenous factors on transplacental mutagenesis
Mutagenesis, ISSN: 0267-8357, Vol: 2, Issue: 3, Page: 173-177
1987
- 4Citations
- 7Captures
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Article Description
Cyclophosphamide (CP)-induced micronuclei were evaluated in females of two strains of mice (C57BL and CD1), in F hybrid females and in fetuses (day 13 of gestation) obtained from different crosses. F adult hybrids from a cross between the strain with a high level of induced micronuclei (C57BL) and the strain with a low response (CD1) exhibited micronuclei values closer to the latter. CD1/CD1 fetuses showed a higher susceptibility than C57BL/C57BL ones. Heterozygous fetuses from reciprocal crosses, whatever the maternal genotype, showed the same sensitivity, which is very close to that of C57BL/C57BL fetuses. Phenobarbital (PB) pre-treatment modified the mutagenic response to CP depending on the genotype of the treated animal. These results demonstrate that the response to a pro-mutagen requiring metabolic activation depends to a large extent on the genetic background of the target animals, and that mother-fetus interactions in transplacental mutagenesis seem to depend more on the fetal than on the maternal genotype. © 1987 IRL Press Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023261917&origin=inward; http://dx.doi.org/10.1093/mutage/2.3.173; http://www.ncbi.nlm.nih.gov/pubmed/3325740; https://academic.oup.com/mutage/article-lookup/doi/10.1093/mutage/2.3.173; https://dx.doi.org/10.1093/mutage/2.3.173; https://academic.oup.com/mutage/article-abstract/2/3/173/1029634?redirectedFrom=fulltext
Oxford University Press (OUP)
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