Mechanisms of growth inhibition of phytomonas serpens by the alkaloids tomatine and tomatidine
Memorias do Instituto Oswaldo Cruz, ISSN: 1678-8060, Vol: 110, Issue: 1, Page: 48-55
2015
- 23Citations
- 5,385Usage
- 36Captures
- 1Mentions
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Metrics Details
- Citations23
- Citation Indexes22
- 22
- CrossRef11
- Policy Citations1
- Policy Citation1
- Usage5,385
- Full Text Views4,977
- 4,977
- Abstract Views408
- 408
- Captures36
- Readers36
- 36
- Mentions1
- News Mentions1
- News1
Most Recent News
Activity of Piperaceae extracts and fractions in the control of Phytomonas serpens/Atividade de extratos e fracoes de Piperaceae no controle de Phytomonas serpens.(CROP PROTECTION texto en ingles)
INTRODUCTION Species of the Trypanosomatidae family are pathogenic protozoa that cause various diseases, affecting vertebrate animals, humans, and plants. In humans, these flagellates are etiological
Article Description
Phytomonas serpens are flagellates in the family Trypanosomatidae that parasitise the tomato plant (Solanum lycopersicum L.), which results in fruits with low commercial value. The tomato glycoalkaloid tomatine and its aglycone tomatidine inhibit the growth of P. serpens in axenic cultures. Tomatine, like many other saponins, induces permeabilisation of the cell membrane and a loss of cell content, including the cytosolic enzyme pyruvate kinase. In contrast, tomatidine does not cause permeabilisation of membranes, but instead provokes morphological changes, including vacuolisation. Phytomonas treated with tomatidine show an increased accumulation of labelled neutral lipids (BODYPY-palmitic), a notable decrease in the amount of C-alkylated sterols and an increase in zymosterol content. These results are consistent with the inhibition of 24-sterol methyltransferase (SMT), which is an important enzyme that is responsible for the methylation of sterols at the 24 position. We propose that the main target of tomatidine is the sterols biosynthetic pathway, specifically, inhibition of the 24-SMT. Altogether, the results obtained in the present paper suggest a more general effect of alkaloids in trypanosomatids, which opens potential therapeutic possibilities for the treatment of the diseases caused by these pathogens.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923169848&origin=inward; http://dx.doi.org/10.1590/0074-02760140097; http://www.ncbi.nlm.nih.gov/pubmed/25742263; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000100048&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762015000100048&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000100048; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762015000100048; https://dx.doi.org/10.1590/0074-02760140097; https://www.scielo.br/j/mioc/a/XcZm7GhHtKbVh4V7D67YFBd/?lang=en
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