Voxel-based morphometry in alzheimers disease and mild cognitive impairment: Systematic review of studies addressing the frontal lobe
Dementia e Neuropsychologia, ISSN: 1980-5764, Vol: 10, Issue: 2, Page: 104-112
2016
- 14Citations
- 3,683Usage
- 45Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- 14
- Usage3,683
- Full Text Views3,159
- 3,159
- Abstract Views524
- 524
- Captures45
- Readers45
- 45
Article Description
Voxel-based morphometry (VBM) is a useful approach for investigating neurostructural brain changes in dementia. We systematically reviewed VBM studies of Alzheimer’s disease (AD) and mild cognitive impairment (MCI), specifically focusing on grey matter (GM) atrophy in the frontal lobe. Methods: Two searches were performed on the Pubmed database. A set of exclusion criteria was applied to ensure the selection of only VBM studies that directly investigated GM volume abnormalities in AD and/or MCI patients compared to cognitively normal controls. Results: From a total of 46 selected articles, 35 VBM studies reported GM volume reductions in the frontal lobe. The frontal subregions, where most of the volume reductions were reported, included the inferior, superior and middle frontal gyri, as well as the anterior cingulate gyrus. We also found studies in which reduced frontal GM was detected in MCI patients who converted to AD. In a minority of studies, correlations between frontal GM volumes and behavioural changes or cognitive deficits in AD patients were investigated, with variable findings. Conclusion: Results of VBM studies indicate that the frontal lobe should be regarded as an important brain area when investigating GM volume deficits in association with AD. Frontal GM loss might not be a feature specific to late AD only. Future VBM studies involving large AD samples are warranted to further investigate correlations between frontal volume deficits and both cognitive impairment and neuropsychiatric symptoms.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84976444768&origin=inward; http://dx.doi.org/10.1590/s1980-5764-2016dn1002006; http://www.ncbi.nlm.nih.gov/pubmed/29213441; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000200104&lng=en&tlng=en; http://www.scielo.br/pdf/dn/v10n2/1980-5764-dn-10-02-00104.pdf; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1980-57642016000200104&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000200104; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1980-57642016000200104; https://dx.doi.org/10.1590/s1980-5764-2016dn1002006; https://www.scielo.br/j/dn/a/TFSrr4SZc3fFy3Md8yVwNhm/?lang=en
FapUNIFESP (SciELO)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know