Synergistic effect of honey and nigella sativa on wound healing in rats
Acta Cirurgica Brasileira, ISSN: 1678-2674, Vol: 33, Issue: 6, Page: 518-523
2018
- 24Citations
- 3,276Usage
- 82Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef6
- Usage3,276
- Full Text Views3,212
- 3,212
- Abstract Views64
- 64
- Captures82
- Readers82
- 82
Article Description
Purpose: To investigate the therapeutic potential of honey, Nigella sativa (N. sativa) and their combination in rat model of excisional wound healing. Methods: A circular excision wound was established in the back region of 50 Wistar rats. Subsequently, they were divided into 5 groups and daily topical administration of lanolin in the control group, honey in the honey group, cold-pressed N. sativa seed oil in the N. sativa groups, mix of 1:1 ratio of honey and N. sativa seed oil in the mix group, and phenytoin cream in the phenytoin group were used. Then, wound surface areas were evaluated using digital camera immediately after the injury and at post excision days 5, 10, 15 and 20. Results: Significant reduction in wound surface area was observed within and between the groups (P < 0.001). In the post excision days 5, 10, 15 and 20 the wound surface areas in the mix group were significantly lower than the other groups followed by the phenytoin, honey, N. sativa, and control groups. Conclusion: The wound healing may be improved and accelerated by using topical solutions of honey, N. sativa seed oil and especially their mixture.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85050484765&origin=inward; http://dx.doi.org/10.1590/s0102-865020180060000006; http://www.ncbi.nlm.nih.gov/pubmed/30020313; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600518&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502018000600518&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000600518; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502018000600518; https://dx.doi.org/10.1590/s0102-865020180060000006; https://www.scielo.br/j/acb/a/R3GKtQ3MXgmqsbmmBJdgNjJ/?lang=en
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