Sex differences in outcome after implantable cardioverter defibrillator implantation in nonischemic cardiomyopathy.

Citation data:

American heart journal, ISSN: 1097-6744, Vol: 156, Issue: 2, Page: 367-72

Publication Year:
2008
Usage 172
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Citations 36
Citation Indexes 36
Repository URL:
https://touroscholar.touro.edu/president_pubs/68
PMID:
18657670
DOI:
10.1016/j.ahj.2008.02.026
Author(s):
Albert, Christine M; Quigg, Rebecca; Saba, Samir; Estes, N A Mark; Shaechter, Andi; Subacius, Haris; Howard, Adam; Levine, Joseph; Kadish, Alan; DEFINITE Investigators
Publisher(s):
Elsevier BV; Mosby; Touro Scholar
Tags:
Medicine; Cardiomyopathies; Defibrillators; Implantable; Disease-Free Survival; Female; Follow-Up Studies; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Sex Factors; Ventricular Dysfunction; Left; Defibrillators, Implantable; Ventricular Dysfunction, Left; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Cardiovascular Diseases
article description
Women have been underrepresented in randomized trials of implantable cardioverter defibrillator (ICD) therapy, and limited data suggest that women may not benefit from prophylactic ICD implantation to the same extent as men. In the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial, a reduction in all-cause mortality was seen in men (P = .018) but not for women (P = .76).