Treatment Outcomes in Infections Caused by "SPICE" (Serratia, Pseudomonas, Indole-positive Proteus, Citrobacter, and Enterobacter) Organisms: Carbapenem versus Noncarbapenem Regimens.

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Clinical therapeutics, ISSN: 1879-114X, Vol: 39, Issue: 1, Page: 170-176

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Moy, Stanley; Sharma, Roopali
Elsevier BV; Touro Scholar
Pharmacology, Toxicology and Pharmaceutics; Medicine; AmpC β-lactamase; bacteremia; carbapenem; urinary tract infection; Pharmacy and Pharmaceutical Sciences
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article description
Techniques used to identify AmpC β-lactamases in SPICE (Serratia, Pseudomonas, indole-positive Proteus, Citrobacter, and Enterobacter) organisms are not yet optimized for the clinical laboratory and are not routinely used. Clinicians are often left with an uncertainty on the choice of antibiotic when a SPICE organism is isolated. The purpose of this study was to evaluate the outcomes of carbapenem versus noncarbapenem regimens in treating bacteremia or urinary tract infection from a SPICE organism in clinical practice.