Regulation of coronary blood flow in health and ischemic heart disease.

Citation data:

Progress in cardiovascular diseases, ISSN: 1873-1740, Vol: 57, Issue: 5, Page: 409-22

Publication Year:
Usage 180
Abstract Views 110
Link-outs 70
Captures 91
Readers 86
Exports-Saves 5
Social Media 1
Tweets 1
Citations 40
Citation Indexes 40
Dirk J. Duncker; Akos Koller; Daphne Merkus; John M. Canty Jr.
Elsevier BV
Most Recent Tweet View All Tweets
review description
The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been incorporated into the management of patients with ischemic heart disease (IHD). The basic understanding of the fluid mechanical behavior of coronary stenoses has also been translated to the cardiac catheterization laboratory where measurements of coronary pressure distal to a stenosis and coronary flow are routinely obtained. However, the role of perturbations in coronary microvascular structure and function, due to myocardial hypertrophy or coronary microvascular dysfunction, in IHD is becoming increasingly recognized. Future studies should therefore be aimed at further improving our understanding of the integrated coronary microvascular mechanisms that control coronary blood flow, and of the underlying causes and mechanisms of coronary microvascular dysfunction. This knowledge will be essential to further improve the treatment of patients with IHD.