GRAS determination scientific procedures and possible alternatives.

Citation data:

Regulatory toxicology and pharmacology : RTP, ISSN: 1096-0295, Vol: 79 Suppl 2, Page: S105-11

Publication Year:
2016
Usage 27
Abstract Views 25
Link-outs 2
Captures 18
Readers 18
PMID:
27328372
DOI:
10.1016/j.yrtph.2016.06.015
Author(s):
Williams, Gary M; Kobets, Tetyana; Iatropoulos, Michael J; Duan, Jian-Dong; Brunnemann, Klaus D
Publisher(s):
Elsevier BV
Tags:
Pharmacology, Toxicology and Pharmaceutics
review description
The use of a food substance is Generally Recognized as Safe (GRAS) through scientific procedures or experience based on common use in food. The pivotal data used for GRAS determination must be of common knowledge and should include evidence for safety under the conditions of intended use of the substance. Such evidence includes data on the identity and specifications of the substance, its properties of absorption, distribution, metabolism and excretion, and depending on the level of concern, data on genotoxicity, acute and subchronic toxicity, reproductive and developmental toxicity and carcinogenicity. Several alternative procedures can be used as the replacement for standard scientific procedures in order to improve the GRAS process.