Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling.

Citation data:

Oncogene, ISSN: 0950-9232, Vol: 21, Issue: 22, Page: 3651-8

Publication Year:
2002
Usage 26
Abstract Views 23
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Captures 5
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Citations 33
Citation Indexes 33
PMID:
12032867
DOI:
10.1038/sj.onc.1205380
Author(s):
Joseph, Troy; Bryant, Annika; Frankel, Paul; Wooden, Roger; Kerkhoff, Eugen; Rapp, Ulf R; Foster, David A
Publisher(s):
Springer Nature
Tags:
Biochemistry, Genetics and Molecular Biology
article description
Low level expression of an active Raf kinase results in a transformed phenotype; however, high intensity Raf signals block cell cycle progression. Phospholipase D (PLD) has been implicated in regulating cell cycle progression and PLD activity is elevated in Raf transformed cells. We report here that high intensity Raf signals reduce PLD activity and that elevated expression of either PLD1 or PLD2 prevents cell cycle arrest induced by high intensity Raf signals. Overexpression of either PLD1 or PLD2 also reversed increases in p21(Cip1) and protein kinase C delta (PKC delta) cleavage seen with high intensity Raf signals. These data indicate that PLD signaling provides a novel survival signal that overcomes cell cycle arrest induced by high intensity Raf signaling.