Golden mussel is corrosive to concrete and anti-fouling coating is a relatively feasible and efficient method for control of its corrosion. Quantifying the corrosion and finding optimal anti-fouling coating materials are of great significance to the control of bio-fouling on hydraulic structures such as Guangdong pumped-storage plants. In this study, we have conducted a natural attachment experiment of nine months long to study the influence of golden mussel corrosion and the performances of commercially available coatings of 15 types: polyurea, silane, epoxy resin, etc. The capabilities of anti-fouling and anti-corrosion were evaluated using measurements of attachment density and physical-mechanical properties. The results show that after nine months of golden mussel attachment, the compressive strength of concrete was reduced by 21%, the porosity and average pore diameter of concrete increased by 29.3% and 31.5% respectively, and carbonation depth of concrete increased by 29.7%. Polyurea 2, epoxy resin 2, and silane impregnation showed the best in anti-fouling; Polyurea 2, epoxy resin 2, and modified elastic epoxy resin showed the best in anti-corrosion. Thus, polyurea 2 and epoxy resin 2 are recommended as the optimal anti-fouling coating materials.