Potential and limitations of Klebsiella pneumoniae as a microbial cell factory utilizing glycerol as the carbon source.

Citation data:

Biotechnology advances, ISSN: 1873-1899, Vol: 36, Issue: 1, Page: 150-167

Publication Year:
2018
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Repository URL:
http://scholarworks.unist.ac.kr/handle/201301/23084
PMID:
29056473
DOI:
10.1016/j.biotechadv.2017.10.004
Author(s):
Kumar, Vinod; Park, Sunghoon
Publisher(s):
Elsevier BV; PERGAMON-ELSEVIER SCIENCE LTD
Tags:
Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Immunology and Microbiology; Klebsiella pneumoniae; Glycerol; 3-Hydroxypropionic acid; 1,3-Propanediol; 2,3-Butanediol; Lactic acid; Ethanol
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review description
Klebsiella pneumoniae is a Gram-negative facultative anaerobe that metabolizes glycerol efficiently under both aerobic and anaerobic conditions. This microbe is considered an outstanding biocatalyst for transforming glycerol into a variety of value-added products. Crude glycerol is a cheap carbon source and can be converted by K. pneumoniae into useful compounds such as lactic acid, 3-hydroxypropionic acid, ethanol, 1,3-propanediol, 2,3-butanediol, and succinic acid. This review summarizes glycerol metabolism in K. pneumoniae and its potential as a microbial cell factory for the production of commercially important acids and alcohols. Although many challenges remain, K. pneumoniae is a promising workhorse when glycerol is used as the carbon source.