Increased NFAT5 expression stimulates transcription of Hsp70 in preeclamptic placentas.
- Citation data:
Placenta, ISSN: 1532-3102, Vol: 35, Issue: 2, Page: 109-16
- Publication Year:
- Repository URL:
- Medicine; Biochemistry, Genetics and Molecular Biology; HIF-1α; Hsp70; NFAT5; Preeclamptic placenta
We investigated the expression of heat shock protein 70 (Hsp70), nuclear factor of activated T cells 5 (NFAT5), and hypoxia-induced factor-1α (HIF-1α) in the placentas of normal and preeclamptic pregnancies and in human placental hypoxia models in vitro to examine the regulatory mechanisms of placental Hsp70 expression.