Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation.

Citation data:

Scientific reports, ISSN: 2045-2322, Vol: 7, Page: 44921

Publication Year:
2017
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Repository URL:
http://scholarworks.unist.ac.kr/handle/201301/21909
PMID:
28368052
DOI:
10.1038/srep44921
Author(s):
Yang, Yong Ryoul; Song, Seungju; Hwang, Hongsik; Jung, Jung Hoon; Kim, Su-Jeong; Yoon, Sora; Hur, Jin-Hoe; Park, Jae-Il; Lee, Cheol; Nam, Dougu; Seo, Young Kyo; Kim, Joung-Hun; Rhim, Hyewhon; Suh, Pann-Ghill Show More Hide
Publisher(s):
Springer Nature; NATURE PUBLISHING GROUP
Tags:
Multidisciplinary
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article description
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga mice which have an increased level of O-GlcNAcylation, and found that Oga mice exhibited impaired spatial learning and memory. Consistent with this result, Oga mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-O-GlcNAcylation in learning and memory.