Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation.

Citation data:

Chemical communications (Cambridge, England), ISSN: 1364-548X, Vol: 53, Issue: 75, Page: 10394-10397

Publication Year:
2017
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Repository URL:
http://scholarworks.unist.ac.kr/handle/201301/22859
PMID:
28876024
DOI:
10.1039/c7cc05794f
Author(s):
Lee, Jae Bin; Kang, Mi Eun; Kim, Joohee; Lee, Chang Young; Kee, Jung-Min; Myung, Kyungjae; Park, Jang-Ung; Hong, Sung You
Publisher(s):
Royal Society of Chemistry (RSC); The Royal Society of Chemistry; ROYAL SOC CHEMISTRY
Tags:
Chemical Engineering; Materials Science; Chemistry
article description
Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C-H fluorination.