Fabrication and Characterization of Collagen-Immobilized Porous PHBV/HA Nanocomposite Scaffolds for Bone Tissue Engineering

Citation data:

Journal of Nanomaterials, ISSN: 1687-4110, Vol: 2012, Page: 1-11

Publication Year:
2012
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Repository URL:
https://doi.org/10.1155/2012/171804; http://scholarworks.unist.ac.kr/handle/201301/16945
DOI:
10.1155/2012/171804
Author(s):
Baek, Jin-Young; Xing, Zhi-Cai; Kwak, Giseop; Yoon, Keun-Byoung; Park, Soo-Young; Park, Lee Soon; Kang, Inn-Kyu
Publisher(s):
Hindawi Limited; Journal of Nanomaterials; HINDAWI PUBLISHING CORPORATION
Tags:
Materials Science; NANOFIBROUS SCAFFOLDS; SURFACE MODIFICATION; OSTEOBLAST ADHESION; CELL ATTACHMENT; IN-VITRO; COMPOSITE; HYDROXYAPATITE; PROLIFERATION; POLYESTERS; MATRICES
article description
The porous composite scaffolds (PHBV/HA) consisting of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and hydroxyapatite (HA) were fabricated using a hot-press machine and salt-leaching. Collagen (type I) was then immobilized on the surface of the porous PHBV/HA composite scaffolds to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite scaffolds (PHBV/HA/Col) were investigated using a scanning electron microscope (SEM), Fourier transform infrared (FTIR), and electron spectroscopy for chemical analysis (ESCA). The potential of the porous PHBV/HA/Col composite scaffolds for use as a bone scaffold was assessed by an experiment with osteoblast cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation. The results showed that the PHBV/HA/Col composite scaffolds possess better cell adhesion and significantly higher proliferation and differentiation than the PHBV/HA composite scaffolds and the PHBV scaffolds. These results suggest that the PHBV/HA/Col composite scaffolds have a high potential for use in the field of bone regeneration and tissue engineering. Copyright © 2012 Jin-Young Baek et al.