Violacein: Properties and Production of a Versatile Bacterial Pigment.

Citation data:

BioMed research international, ISSN: 2314-6141, Vol: 2015, Page: 465056

Publication Year:
2015
Usage 59
Abstract Views 41
Full Text Views 18
Captures 155
Readers 155
Mentions 2
References 1
Blog Mentions 1
Social Media 5
Tweets 4
Shares, Likes & Comments 1
Citations 26
Citation Indexes 26
Repository URL:
http://scholarworks.unist.ac.kr/handle/201301/9889
PMID:
26339614
DOI:
10.1155/2015/465056
PMCID:
PMC4538413
Author(s):
Choi, Seong Yeol; Yoon, Kyoung-hye; Lee, Jin Il; Mitchell, Robert J.
Publisher(s):
Hindawi Limited; BioMed Research International; HINDAWI PUBLISHING CORPORATION
Tags:
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; CHROMOBACTERIUM-VIOLACEUM; CAENORHABDITIS-ELEGANS; VIOLET PIGMENT; JANTHINOBACTERIUM-LIVIDUM; PSYCHROTROPHIC BACTERIUM; ANTIBIOTIC PRODUCTION; BIOSYNTHETIC-PATHWAY; CHEMICAL DEFENSE; DRUGS VIOLACEIN; CANCER CELLS; Biotechnology
Most Recent Tweet View All Tweets
Most Recent Blog Mention
review description
Violacein-producing bacteria, with their striking purple hues, have undoubtedly piqued the curiosity of scientists since their first discovery. The bisindole violacein is formed by the condensation of two tryptophan molecules through the action of five proteins. The genes required for its production, vioABCDE, and the regulatory mechanisms employed have been studied within a small number of violacein-producing strains. As a compound, violacein is known to have diverse biological activities, including being an anticancer agent and being an antibiotic against Staphylococcus aureus and other Gram-positive pathogens. Identifying the biological roles of this pigmented molecule is of particular interest, and understanding violacein's function and mechanism of action has relevance to those unmasking any of its commercial or therapeutic benefits. Unfortunately, the production of violacein and its related derivatives is not easy and so various groups are also seeking to improve the fermentative yields of violacein through genetic engineering and synthetic biology. This review discusses the recent trends in the research and production of violacein by both natural and genetically modified bacterial strains.