Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes.
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Expert opinion on therapeutic targets, ISSN: 1744-7631, Vol: 20, Issue: 6, Page: 677-87
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- Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Myelodysplastic syndromes; nuclear inositides; PI-PLCbeta1; PI-PLCgamma1; PI3K/Akt/mTOR
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Nuclear inositide signaling pathways specifically regulate cell proliferation and differentiation. Interestingly, the modulation of nuclear inositides in hematological malignancies can differentially affect erythropoiesis or myelopoiesis. This is particularly important in patients with myelodysplastic syndromes (MDS), who show both defective erythroid and myeloid differentiation, as well as an increased risk of evolution into acute myeloid leukemia (AML).