Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein Structural Parameters

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Algorithms, ISSN: 1999-4893, Vol: 2, Issue: 3, Page: 1155-1176

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John Hixon; Yana K. Reshetnyak
MDPI AG; DigitalCommons@URI
Biological Sciences; Engineering
Mathematics; Computer Science; fluorescence; tryptophan; fluorophores; proteins; fluorescence; tryptophan; fluorophores; proteins; Physics
article description
The fluorescence properties of tryptophan residues are sensitive to the microenvironment of fluorophores in proteins. Therefore, fluorescence characteristics are widely used to study structural transitions in proteins. However, the decoding of the structural information from spectroscopic data is challenging. Here we present a review of approaches developed for the decomposition of multi-component protein tryptophan fluorescence spectra and correlation of these spectral parameters with protein structural properties.