Factores de riesgo asociados al desarrollo de bacteriemia en pacientes adultos cirróticos hospitalizados

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instname:Universidad del Rosario

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Sánchez Monroy, Diana Lorena; Especialista en Medicina Interna
Facultad de Medicina; Universidad del Rosario
Cirrosis hepática; bacteriemia; infecciones torrente sanguíneo; epidemiología; 616; Medicina interna; Liver Cirrhosis; bacteremia; bloodstream infections; epidemiology; Kang CI, Song JH, Chung DR, Peck KR, Yeom JS, Ki HK, et al. Liver cirrhosis as a risk factor for mortality in a national cohort of patients with bacteremia. J Infect. Elsevier Ltd; 2011;63(5):336–43.; Medicina inerna; Epidemiología; Bacteriemia; Infectología
thesis / dissertation description
Introduction: bacteremia in cirrhotic patients is an important cause of morbidity and mortality, favored by the particular vulnerability of this population to infectious diseases. The objective was to determine the factors associated with the development of primary and secondary bacteremia in patients with cirrhosis hospitalized in the Fundación Cardioinfantil - Instituto de Cardiología between January 1, 2010 and January 31, 2016. Materials and Methods: Case-control study in patients over 18 years with liver cirrhosis known or confirmed during hospitalization. A descriptive analysis was performed, bivariate analysis was done to determine differences between cases and controls with respect to the independent variables, association analysis was done using a model of unconditional logistic regression with bacteremia as a dependent variable. The results are expressed in odds ratios with confidence intervals at 95%. Results: Factors associated with bacteremia as risk factors were: chronic kidney disease OR 9.1 (95% CI 2.4 to 34), Meld score > 10 points OR 4.0 (95% CI 2 -34) previous infection OR 7.2 (95% CI 2.1 to 24), presence of central catheter OR 12.0 (95% CI 1.8 to 80), presence of urinary catheter OR 21.1 (95% CI 1 6-276), endoscopy OR 3.9 (95% CI 1.1 to 14). Discussion: Factors related to the patient's clinical condition assessed by the Child-Pugh and Meld scores, history of previous infection and the presence of devices to monitor the patient's condition increase the risk of bacteremia in hospitalized patients with cirrhosis.