Toxina botulinica como profilaxis de migraña

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instname:Universidad del Rosario

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Paz Abdala, Jairo Andrés; Rodríguez Quintana, Jesús Hernán; Restrepo, Héctor Fabio; Especialista en Neurología
Facultad de Medicina; Universidad del Rosario
migraña; cefalea; toxina botulinica; prevencion y control; Cabeza::Enfermedades; CABEZA - ENFERMEDADES - PREVENCION; Cefalalgia; Migraña::Control; MIGRAÑA - PREVENCION; Neurología; migraine; headache disorders; botulinum toxins; prevention and control; CABEZA - ENFERMEDADES - CONTROL; CEFALALGIA; MIGRAÑA - CONTROL; NEUROLOGIA
thesis / dissertation description
The migraine syndrome is the best known primary headache. It is a disabling disorder of fluctuating course, with significant impact on quality life of patients and high economic costs as it usually develops in most productive years of the person, as well as high costs for the system. The goal is remove the crises, for these reasons one of the cornerstones of treatment is preventing attacks. Multiple medications have been studied, in recent years botulinum toxin has aroused enthusiasm. OBJECTIVES: To establish if botulinum toxin in an effective medication preventing migraine crises. METHODS: Databases such as MEDLINE, the Cochrane Library and LILACS were consulted to have access to published literature from January 1966 to September 2007. All articles published in English and Spanish were considered. Studies that examined the frequency and intensity response to medication were elegible. RESULTS: Three studies met the proposed criteries, two of them don’t show a clear benefit concerning placebo. CONCLUSIONS: At this moment with the available literature, there is not sufficient evidence to conclude if botulinum toxin is an effective medication in the profilactic treatment of migraine.