VIH/Sida : desenlaces clínicos a largo plazo de una cohorte que asistió a un programa de atención integral durante 2005-2016

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Palencia Boada, María Angélica; Hernandez Castro, Laura Carolina; Especialista en Epidemiología (en Convenio con el CES)
Facultad de medicina
VIH; SIDA; Terapia antiretroviral altamente efectiva; Supervivencia; Infecciones oportunistas relacionadas con SIDA; Research Subject Categories::MEDICINE; 616.9792; Enfermos de sida; Personas VIH positivas; Infecciones por VIH; HIV; AIDS; Survival; Antiretroviral therapy highly effective; AIDS related opportunistic infections; HIV long term survivors
thesis / dissertation description
Antiretroviral therapy is the main determinant in the survival of patients with HIV; the social environment, the management of comorbidities and the ease of access to the health system also modify the outcome. A longitudinal analytical observational study was conducted, from a cohort of patients who attended during 2005 - 2016 to a comprehensive HIV / AIDS care program in the city of Bogotá. Data from 1105 patients were evaluated, the average age of onset of treatment was 35.0 ± 9.5 years and the mortality was 3.3% (n = 37). A significant difference was found in the cumulative survival by age groups (p = 0.001, Log-Rank test), showing greater survival in the younger age groups. There was a greater significant risk of mortality in smokers (p = 0.015), without immunity for hepatitis B (p <0.001), low weight (p = 0.016), with a count lower than 200 cel / mm3 (p = 0.001) and those with viral loads greater than 500 copies / ml (p <0.001). No significant differences were found according to type of hospitalizations presented or associated pathology. There was a significant decrease in mortality in those with immunity against hepatitis B (p = 0.006). HIV is a chronic disease, survival in these patients is due to variables other than treatment and immuno-virological status. Exploring the influence of sociodemographic factors, comorbidities, clinical status and adequate care in comprehensive HIV care programs that guarantee complete care, positively influences the life expectancy of people living with HIV / AIDS.