Asociación entre niveles séricos de progesterona y embarazo en pacientes tratadas con técnicas de reproducción asistida

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reponame:Repositorio Institucional EdocUR

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Sandra Paola, González Gaitán; Viviana Lizeth, Guzmán Herrera; Especialista en Epidemiología (en Convenio con el CES);
Facultad de medicina; Universidad del Rosario
Progesterona; Técnicas de reproducción asistida; Embarazo; Esterilidad; Tecnología reproductiva humana; Progesterone; Assisted reproductive techniques; Pregnancy; EMBARAZO; ESTERILIDAD; TECNOLOGIA REPRODUCTIVA HUMANA
thesis / dissertation description
Introduction: Infertility affects approximately 15% of of reproductive-aged patients. Assisted reproductive techniques represent 30% of the treatments applied to these couples. Identifying predictors of pregnancy outcome is established as an important tool in the management of these patients. Methods: Observational, retrospective, cohort of study of patients treated at the Fertility Unit of the Country of Bogota (Conceptum) between January 20th, 2005 to December 15th, 2010. The aim was to establish if there are differences in serum progesterone levels in pregnant patients and those without, and the identification of variables associated with successful pregnancy in patients treated with assisted reproductive techniques. Results: 352 cycles of patients were analyzed, 131 pregnant women (110 deliveries, 18 abortions and 2 ectopic). There was a statistically significant association between serum progesterone levels and clinical pregnancy. The cutoff point for serum progesterone levels for the study population was 15ng/mL. The other variables associated with clinical pregnancy were the number of embryos transferred and whether it was frozen or not. Discussion: Serum progesterone levels of 15 ng/mL or less, controlling by single embryo transfer and the fact that there are no extra frozen embryos were associated with the presence of no clinical pregnancy, data consistent with findings from previously published studies. These results are very useful to provide medical advice to patients regarding prognosis of their treatment cycle.