Genetic diversity and selection in three Plasmodium vivax merozoite surface protein 7 (Pvmsp-7) genes in a Colombian population.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 7, Issue: 9, Page: e45962

Publication Year:
2012
Usage 2928
Full Text Views 2345
Abstract Views 400
Downloads 165
Views 18
Captures 31
Readers 28
Exports-Saves 3
Citations 12
Citation Indexes 12
Repository URL:
http://repository.urosario.edu.co/handle/10336/8831; http://repository.urosario.edu.co/handle/10336/8768
PMID:
23049905
DOI:
10.1371/journal.pone.0045962; 10.1371/journal.pone.0045962.t001; 10.1371/journal.pone.0045962.t003; 10.1371/journal.pone.0045962.g004; 10.1371/journal.pone.0045962.t002; 10.1371/journal.pone.0045962.g002; 10.1371/journal.pone.0045962.g001; 10.1371/journal.pone.0045962.g003
PMCID:
PMC3458108; 3458108
Author(s):
Diego Garzón-Ospina; Carolina López; Johanna Forero-Rodríguez; Manuel A. Patarroyo; Erika Martins Braga
Publisher(s):
Public Library of Science (PLoS); Universidad del Rosario; Figshare
Tags:
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; 616.9362; CAENORHABDITIS-ELEGANS GENOME; AMINO-ACID SITES; MALARIA PARASITE; POSITIVE SELECTION; INTRAGENIC RECOMBINATION; STATISTICAL TESTS; DEATH EVOLUTION; MSP7 FAMILY; FALCIPARUM; COMPLEX; Malaria; Genoma; Enfermedades infecciosas; Genética; Evolutionary Biology; Immunology; 110309 Infectious Diseases; recombination; fragments; rdp3; deduced; pvmsp-7i; amino; sal-i; sequences; differentiating; allele; types; synonymous; substitutions; non-synonymous; covering; pairs; nucleotide; substitution; nonsynonymous; deviations; dna; neutrality; genes; colombian; Cancer; merozoite; pvmsp-7h; pvmsp-7c
article media
article description
A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine.