Childhood asthma and spirometric indices are associated with polymorphic markers of two vitamin D 25-hydroxylase genes.

Citation data:

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, ISSN: 1399-3038, Vol: 26, Issue: 4, Page: 375-82

Publication Year:
2015
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Repository URL:
http://repository.vtc.edu.hk/thei-fac-sci-tech-sp/345
PMID:
25845986
DOI:
10.1111/pai.12392; 10.1111/pai.12392.
Author(s):
Leung, Ting Fan; Wang, Susan Shuxin; Tang, Man Fung; Kong, Alice Pik-Shan; Sy, Hing Yee; Hon, Kam Lun; Chan, Juliana Chung-ngor; Wong, Gary Wing-kin
Publisher(s):
Wiley-Blackwell; VTC Institutional Repository
Tags:
Medicine; Immunology and Microbiology; 25-hydroxylase; Asthma; Single nucleotide polymorphism; Spirometry; Vitamin D; Pulmonology
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article description
Polymorphic markers of vitamin D pathway genes have been associated with asthma traits in different White populations. This study investigated the relationship between asthma phenotypes and single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR), vitamin D binding protein (GC), two 25-hydroxylases (CYP2R1 and CYP27A1), and 1α-hydroxylase (CYP27B1) in Hong Kong Chinese children.