Tissue perfusion modelling in optical coherence tomography.

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Biomedical engineering online, ISSN: 1475-925X, Vol: 16, Issue: 1, Page: 27

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Stohanzlova, Petra; Kolar, Radim
Springer Nature
Health Professions; Materials Science; Engineering; Medicine; Optical coherence tomography; Perfusion analysis; Deconvolution; Model Phantom; Impulse response
article description
Optical coherence tomography (OCT) is a well established imaging technique with different applications in preclinical research and clinical practice. The main potential for its application lies in the possibility of noninvasively performing "optical biopsy". Nevertheless, functional OCT imaging is also developing, in which perfusion imaging is an important approach in tissue function study. In spite of its great potential in preclinical research, advanced perfusion imaging using OCT has not been studied. Perfusion analysis is based on administration of a contrast agent (nanoparticles in the case of OCT) into the bloodstream, where during time it specifically changes the image contrast. Through analysing the concentration-intensity curves we are then able to find out further information about the examined tissue.