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Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics

Cell, ISSN: 0092-8674, Vol: 186, Issue: 26, Page: 5690-5704.e20
2023
  • 4
    Citations
  • 0
    Usage
  • 19
    Captures
  • 11
    Mentions
  • 2
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    4
  • Captures
    19
  • Mentions
    11
    • News Mentions
      10
      • 10
    • Blog Mentions
      1
      • 1
  • Social Media
    2
    • Shares, Likes & Comments
      2
      • Facebook
        2

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Article Description

The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied considerably in the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage importation and persistence, likely due to a combination of COVID-19 restrictions and changing connectivity. Here, we show that local COVID-19 epidemics are driven by regional transmission, including across international boundaries, but can become increasingly connected to distant locations following the relaxation of public health interventions. By integrating genomic, mobility, and epidemiological data, we find abundant transmission occurring between both adjacent and distant locations, supported by dynamic mobility patterns. We find that changing connectivity significantly influences local COVID-19 incidence. Our findings demonstrate a complex meaning of “local” when investigating connected epidemics and emphasize the importance of collaborative interventions for pandemic prevention and mitigation.

Bibliographic Details

Matteson, Nathaniel L; Hassler, Gabriel W; Kurzban, Ezra; Schwab, Madison A; Perkins, Sarah A; Gangavarapu, Karthik; Levy, Joshua I; Parker, Edyth; Pride, David; Hakim, Abbas; De Hoff, Peter; Cheung, Willi; Castro-Martinez, Anelizze; Rivera, Andrea; Veder, Anthony; Rivera, Ariana; Wauer, Cassandra; Holmes, Jacqueline; Wilson, Jedediah; Ngo, Shayla N; Plascencia, Ashley; Lawrence, Elijah S; Smoot, Elizabeth W; Eisner, Emily R; Tsai, Rebecca; Chacón, Marisol; Baer, Nathan A; Seaver, Phoebe; Salido, Rodolfo A; Aigner, Stefan; Ngo, Toan T; Barber, Tom; Ostrander, Tyler; Fielding-Miller, Rebecca; Simmons, Elizabeth H; Zazueta, Oscar E; Serafin-Higuera, Idanya; Sanchez-Alavez, Manuel; Moreno-Camacho, Jose L; García-Gil, Abraham; Murphy Schafer, Ashleigh R; McDonald, Eric; Corrigan, Jeremy; Malone, John D; Stous, Sarah; Shah, Seema; Moshiri, Niema; Weiss, Alana; Anderson, Catelyn; Aceves, Christine M; Spencer, Emily G; Hufbauer, Emory C; Lee, Justin J; King, Alison J; Ramesh, Karthik S; Nguyen, Kelly N; Saucedo, Kieran; Robles-Sikisaka, Refugio; Fisch, Kathleen M; Gonias, Steven L; Birmingham, Amanda; McDonald, Daniel; Karthikeyan, Smruthi; Martin, Natasha K; Schooley, Robert T; Negrete, Agustin J; Reyna, Horacio J; Chavez, Jose R; Garcia, Maria L; Cornejo-Bravo, Jose M; Becker, David; Isaksson, Magnus; Washington, Nicole L; Lee, William; Garfein, Richard S; Luna-Ruiz Esparza, Marco A; Alcántar-Fernández, Jonathan; Henson, Benjamin; Jepsen, Kristen; Olivares-Flores, Beatriz; Barrera-Badillo, Gisela; Lopez-Martínez, Irma; Ramírez-González, José E; Flores-León, Rita; Kingsmore, Stephen F; Sanders, Alison; Pradenas, Allorah; White, Benjamin; Matthews, Gary; Hale, Matt; McLawhon, Ronald W; Reed, Sharon L; Winbush, Terri; McHardy, Ian H; Fielding, Russel A; Nicholson, Laura; Quigley, Michael M; Harding, Aaron; Mendoza, Art; Bakhtar, Omid; Browne, Sara H; Olivas Flores, Jocelyn; Rincon Rodríguez, Diana G; Gonzalez Ibarra, Martin; Robles Ibarra, Luis C; Arellano Vera, Betsy J; Gonzalez Garcia, Jonathan; Harvey-Vera, Alicia; Knight, Rob; Laurent, Louise C; Yeo, Gene W; Wertheim, Joel O; Ji, Xiang; Worobey, Michael; Suchard, Marc A; Andersen, Kristian G; Campos-Romero, Abraham; Wohl, Shirlee; Zeller, Mark

Elsevier BV

Biochemistry, Genetics and Molecular Biology

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