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Iridium(III)-Catalyzed Direct C-H Sulfonamidation of 2-Aryl-1,2,3-triazole N-Oxides with Sulfonyl Azides

Advanced Synthesis and Catalysis, ISSN: 1615-4169, Vol: 358, Issue: 2, Page: 326-332
2016
  • 41
    Citations
  • 0
    Usage
  • 6
    Captures
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Metrics Details

  • Citations
    41
    • Citation Indexes
      41
  • Captures
    6

Article Description

We have developed a method for the direct sulfonamidation of 2-aryl-1,2,3-triazole N-oxides using sulfonyl azides as the amino source to release molecular nitrogen as the sole by-product. This protocol exhibits excellent functional group tolerance and proceeds efficiently under external oxidant-free conditions. Various 2-(2-sulfonamidoaryl)-1,2,3-triazoles were prepared in up to 97% yields for 25 examples with excellent regioselectivity.

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