Left atrial appendage occlusion: On the need of a numerical model to simulate the implant procedure
International Journal for Numerical Methods in Biomedical Engineering, ISSN: 2040-7947, Vol: 40, Issue: 5, Page: e3814
2024
- 2Citations
- 7Captures
- 1Mentions
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Most Recent News
Polytechnic University Milan Reports Findings in Thromboembolism (Left atrial appendage occlusion: On the need of a numerical model to simulate the implant procedure)
2024 APR 02 (NewsRx) -- By a News Reporter-Staff News Editor at Math Daily News -- New research on Cardiovascular Diseases and Conditions - Thromboembolism
Article Description
Left atrial appendage occlusion (LAAO) is a percutaneous procedure to prevent thromboembolism in patients affected by atrial fibrillation. Despite its demonstrated efficacy, the LAA morphological complexity hinders the procedure, resulting in postprocedural drawbacks (device-related thrombus and peri-device leakage). Local anatomical features may cause difficulties in the device's positioning and affect the effectiveness of the device's implant. The current work proposes a detailed FE model of the LAAO useful to investigate implant scenarios and derive clinical indications. A high-fidelity model of the Watchman FLX device and simplified parametric conduits mimicking the zone of the LAA where the device is deployed were developed. Device-conduit interactions were evaluated by looking at clinical indicators such as device-wall gap, possible cause of leakage, and device protrusion. As expected, the positioning of the crimped device before the deployment was found to significantly affect the implant outcomes: clinician's choices can be improved if FE models are used to optimize the pre-operative planning. Remarkably, also the wall mechanical stiffness plays an important role. However, this parameter value is unknown for a specific LAA, a crucial point that must be correctly defined for developing an accurate FE model. Finally, numerical simulations outlined how the device's configuration on which the clinician relies to assess the implant success (i.e., the deployed configuration with the device still attached to the catheter) may differ from the actual final device's configuration, relevant for achieving a safe intervention.
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