Unexpected low-temperature behaviour of piroxicam monohydrate
ChemPhysChem, ISSN: 1439-4235, Vol: 14, Issue: 4, Page: 675-679
2013
- 5Citations
- 16Captures
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Article Description
Cool runnings: Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Bibliographic Details
Wiley
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