Effect of diabetes mellitus on periprocedural myocardial infarction in patients undergoing coronary stent implantation
Diabetes/Metabolism Research and Reviews, ISSN: 1520-7560, Vol: 31, Issue: 1, Page: 85-92
2015
- 5Citations
- 30Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef3
- Captures30
- Readers30
- 30
Article Description
Background: Diabetic patients undergoing percutaneous coronary interventions are still regarded as a very high risk category because of an increased platelet reactivity and risk of complications, especially in patients with inadequate glycaemic control. However, although its prognostic effect on long-term outcome is well-defined, still unclear is the effect of diabetes on the risk of periprocedural myocardial infarction in patients undergoing percutaneous coronary interventions, which was therefore the aim of our study. Methods: Myonecrosis biomarkers were dosed at intervals from 6 to 48 h after nonemergent percutaneous coronary interventions. Periprocedural myocardial infarction was defined as creatine kinase-MB increase by three times the upper limit normal or by 50% of an elevated baseline value, whereas periprocedural myonecrosis as troponin I increase by three times the upper limit normal or 50% of baseline. Results: Of 1311 patients, diabetes mellitus was found in 458 patients (34.9%) and associated with age (p=0.03), hypertension (p<0.001), renal failure (p=0.01), previous MI (p=0.03), previous coronary revascularization (p<0.001), higher fasting glycaemia and lower haemoglobin (p<0.001), more severe coronary disease (p<0.001), multivessel percutaneous coronary interventions (p=0.03), coronary calcification (p=0.003) and in-stent restenosis (p<0.001) but lower presence of thrombus (p=0.03). Diabetic patients were receiving significantly more frequent specific pharmacological treatment at admission. Diabetic status did not influence the risk of periprocedural myocardial infarction or periprocedural myonecrosis [adjusted OR(95%CI)=0.90(0.64-1.27), p=0.57 and adjusted OR(95%CI)=0.92(0.70-1.21), p=0.55]. Amongst diabetic patients, we did not observe any effect of chronic glycaemic control on periprocedural myocardial infarction. Conclusions: Diabetic status, independent of chronic glycaemic control, is not associated with increased risk of periprocedural myocardial infarction and myonecrosis in patients undergoing percutaneous coronary interventions.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920997628&origin=inward; http://dx.doi.org/10.1002/dmrr.2567; http://www.ncbi.nlm.nih.gov/pubmed/24898423; https://onlinelibrary.wiley.com/doi/10.1002/dmrr.2567; http://doi.wiley.com/10.1002/dmrr.2567; http://onlinelibrary.wiley.com/doi/10.1002/dmrr.2567/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+24th+October+2015+at+10%3A00-10%3A30+BST+%2F+05%3A00-05%3A30+EDT+%2F+17%3A00-17%3A30++SGT++for+essential+maintenance.++Apologies+for+the+inconvenience
Wiley
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