Age-related changes in astrocytic and ependymal cells of the subventricular zone
GLIA, ISSN: 1098-1136, Vol: 62, Issue: 5, Page: 790-803
2014
- 78Citations
- 148Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations78
- Citation Indexes78
- 78
- CrossRef59
- Captures148
- Readers148
- 148
- Mentions1
- Blog Mentions1
- Blog1
Article Description
Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence. © 2014 Wiley Periodicals, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896316261&origin=inward; http://dx.doi.org/10.1002/glia.22642; http://www.ncbi.nlm.nih.gov/pubmed/24677590; https://onlinelibrary.wiley.com/doi/10.1002/glia.22642; http://doi.wiley.com/10.1002/glia.22642; https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.22642; https://onlinelibrary.wiley.com/doi/full/10.1002/glia.22642; https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.22642; http://onlinelibrary.wiley.com/doi/10.1002/glia.22642/abstract
Wiley
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